posted on 2022-06-20, 09:39authored bySizheng ZhaoSizheng Zhao, John Bowes, Anne Barton, George Davey Smith, Tom G. Richardson
<p>This file lists variants used as instrumental variables for the manuscript "Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study".</p>
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<p>We selected independent (linkage disequilibrium threshold of r2<0.001 using PLINK and a reference panel of 10,000 randomly selected Europeans from UK Biobank) genome-wide significant (p<5x10-8) SNPs, resulting in 313 childhood and 580 adult body size instruments. For multivariable MR, we repeated LD clumping for the combined set of SNPs from both exposures. </p>
Funding
Versus Arthritis (grant number 21173, grant number 21754 and grant number 21755)